Contact Us Search this website Neda Frayha nedafrayha of Primary Care RAP Hippo Education joins us this month for our thoughts and analysis of some recent and not so recent journal articles that interested us this month. Our articles spanned topics that include at cancer survival among patients pursuing treatment with complementary medicine, the effect of body weight on effectiveness of preventive aspirin dosing, strategies to promote physician leadership, respiratory symptoms in those with marijuana use and MRSA risk among patients with penicillin allergies. Join our mailing list to receive a PDF copy of our show notes every Monday!
Dawn Connelly is an award-winnin features editor at the Pharmaceutical Journal. She has worked in both hospital and community pharmacy and has over 10 years of experience in pharmacy journalism.
InDawn took the Data Journalism prize for an impressive info-graphic charting The Ebola virus outbreak.
One of the first drugs to come into common usage, aspirin is still one of the most researched drugs in the world, with an estimated to 1, clinical trials conducted each year. Aspirin is one of the most common drugs with an estimated to 1, clinical trials conducted each year c — BC: Willow is used as a medicine by ancient civilisations like the Sumerians and Egyptians.
The Ebers papyrus, an ancient Egyptian medical text, refers to willow as an anti-inflammatory or pain reliever for non-specific aches and pains.
In Greece, Hippocrates administers willow leaf tea, which contains the natural compound from which aspirin is derived, to women to ease the pain of childbirth.
The Royal Society publishes a report detailing five years of experiments on the use of dried, powdered willow bark in curing fevers, submitted by Edward Stone, a vicar in Chipping Norton, Oxfordshire.
Joseph Buchner, professor of pharmacy at Munich University, Germany, succeeds in extracting the active ingredient from willow, producing bitter tasting yellow crystals that he names salicin. The first rigorous clinical trial of salicin finds that it induces remission of fever and joint inflammation in patients with rheumatism Lancet ;1: Acetylsalicyclic acid is named Aspirin by Bayer.
Aspirin enters the Guinness World Records for being the most frequently sold painkiller. Results from the CAST Chinese acute stroke trial study of early aspirin use in 20, patients with acute ischaemic stroke show that aspirin started early in hospital produces a small but definite net benefit Lancet ; Results from the HOT hypertension optimal treatment trial show that aspirin significantly reduces major cardiovascular events in hypertensive patients, with the greatest benefit seen in preventing heart attacks.
The incidence of non-fatal major bleeds was twice as common Lancet ;; A meta-analysis by the ATT antithrombotic trialists collaboration suggests that aspirin has substantial overall benefit in secondary prevention but in primary prevention, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds Lancet ; The results also show increased risk of gastrointestinal bleeding and peptic ulcers Annals of Internal Medicine ; A meta-analysis suggests that long-term prophylactic use of aspirin has a favourable benefit—harm profile and leads to a dramatic reduction in the incidence of bowel, stomach and oesophageal cancer Annals of Oncology, online 5 August Results expected from the ASPREE aspirin in reducing events in the elderly study to determine whether the potential benefits of low-dose aspirin outweigh the risks in healthy people older than 70 years of age.The results also show increased risk of gastrointestinal bleeding and peptic ulcers (Annals of Internal Medicine ;).
A meta-analysis suggests that long-term prophylactic use of aspirin has a favourable benefit–harm profile and leads to a dramatic reduction in the incidence of bowel, stomach and oesophageal cancer (Annals of Oncology, online 5 August ).
The main ingredient in aspirin, salicin, is the oldest pain reliever in history, but it took time and science before it became the drug we recognize today. Aspirin’s role in causing major bleeding was less clear in the analysis: A review of seven trials found virtually no difference among aspirin users and nonusers, although there was a trend toward more major bleeding with aspirin and researchers said there wasn’t enough data to draw a definite conclusion.
After recrystallisation differences between the crude and purified aspirin were noted.
The impure (crude) aspirin was powered and fluffy with small clumps and was slightly yellow in colour whereas the pure aspirin has a less fluffy crystalline powder and was whiter. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, naproxen, or an NSAID.
Aspirin side effects Get emergency medical help if you have signs of an allergic reaction to aspirin: hives; difficult breathing; swelling of . Management Of Patients Taking Antiplatelet Drugs. Antiplatelet drugs have scarce data with regard to their management in surgical patients.
The most commonly prescribed antiplatelet agents are clopidogrel (Plavix), dipyridamole .